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Immunohistochemical study of epidermal growth factor and epidermal growth factor receptor in gastric carcinoma
Author(s) -
Sugiyama Kazuo,
Yonemura Yutaka,
Miyazaki Itsuo
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890415)63:8<1557::aid-cncr2820630818>3.0.co;2-y
Subject(s) - epidermal growth factor receptor , epidermal growth factor , immunohistochemistry , pathology , autocrine signalling , carcinoma , medicine , tgf alpha , cancer , growth factor receptor inhibitor , epithelioma , growth factor , receptor , biology
Immunohistochemical study for epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) was performed on 222 specimens of gastric carcinoma. The authors placed each carcinoma into one of the following three groups: group 1, neither EGF nor EGFR was stained (123 cases); group 2, either EGF or EGFR was stained (64 cases); and group 3, both EGF and EGFR were stained (35 cases). Compared with the carcinomas in groups 1 and 2, those in group 3 had significantly higher rates of infiltrative gross type, microscopically infiltrative type, poorly differentiated type, scirrhous type, and deep invading type. These results suggest that carcinomas in group 3 may have more proliferative and invasive activity and thus may have an autocrine mechanism, that is, the ability of cancer cells to produce and respond to their own growth factor.