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Cutaneous malignant melanoma. II. The natural history and prognostic factors influencing the development of stage II disease
Author(s) -
Berdeaux Donald H.,
Meyskens Frank L.,
Parks Bruce,
Tong Tony,
Loescher Lois,
Moon Thomas E.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890401)63:7<1430::aid-cncr2820630733>3.0.co;2-g
Subject(s) - medicine , melanoma , stage (stratigraphy) , breslow thickness , natural history , proportional hazards model , multivariate analysis , oncology , disease , nodal , cancer , gastroenterology , paleontology , sentinel lymph node , cancer research , breast cancer , biology
The survival history of 259 patients with Stage I cutaneous malignant melanoma who were at risk for developing regional nodal metastases (Stage II) were studied. Eighty‐seven of 377 Stage I patients (23%) developed regional nodal metastases (Stage H B ) with 40% 5‐year survival. Fifty patients had regional nodal metastases at presentation, with or without a known primary (Stages II A or lie, respectively), with a 42% 5‐year survival. A step‐down multivariate analysis using the Cox regression model revealed four risk factors as being highly significant for predicting a more favorable survival outcome: (1) thinner Breslow thickness (P = 0.0001), (2) pathologic Stage I disease (P = 0.004), (3) no clinical ulceration (P = 0.0004), and (4) being a woman younger than 50 years of age (P = 0.029). These results are discussed in reference to other series.