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Multiple carcinoids and endocrine cell micronests in type a gastritis. Their morphology, histogenesis, and natural history
Author(s) -
Itsuno Minoru,
Watanabe Hidenobu,
Iwafuchi Mitsuya,
Ito Seiki,
Yanaihara Noboru,
Sato Koji,
Kikuchi Masanori,
Akiyama Nobuhiro
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890301)63:5<881::aid-cncr2820630515>3.0.co;2-k
Subject(s) - atrophic gastritis , histogenesis , gastrin , intestinal metaplasia , pathology , foveolar cell , gastric chief cell , enteroendocrine cell , medicine , enterochromaffin like cell , stomach , metaplasia , gastric mucosa , endocrine system , gastritis , immunohistochemistry , secretion , hormone
Abstract Six cases of type A gastritis associated with multiple carcinoids and/or endocrine cell micronests (ECM) in the atrophic fundic mucosa were examined light microscopically, immunohistochemically, and ultrastructurally. The ECM and carcinoids were mainly composed of enterochromaffin‐like (ECL) cells. The cells were hyperplastic only in the atrophic fundic glands and pseudopyloric glands, but not in the intestinal metaplastic gland. It is suggested that the development of both the ECM and the carcinoids is highly related to the atrophic change of the fundic mucosa and a trophic action of subsequently raised serum gastrin in type A gastritis and that the both lesions arise from the pseudopyloric glands or atrophic fundic glands. In addition, the definition of neoplastic ECM (microcarcinoid) of the stomach was made with comparative study on both the cases with ECM and multiple carcinoids and the cases with ECM alone.