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Characterization of a human ovarian carcinoma cell line with estrogen and progesterone receptors
Author(s) -
Geisinger Kim R.,
Kute Timothy E.,
Pettenati Mark J.,
Welander Charles E.,
Dennard Yvonne,
Collins Lee Ann,
Berens Michael E.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890115)63:2<280::aid-cncr2820630213>3.0.co;2-n
Subject(s) - progesterone receptor , receptor , estrogen , medicine , estrogen receptor , endocrinology , karyotype , ovarian carcinoma , ovary , ovarian cancer , carcinoma , cancer research , biology , cancer , breast cancer , chromosome , genetics , gene
The potential significant therapeutic and prognostic roles for the sex steroid receptors in ovarian cancer are recognized. The authors present in detail the biochemical, morphologic, cytogenetic, and growth characteristics of an ovarian carcinoma cell line, BG‐1, which has functional estrogen and progesterone receptors (23 and 300 fmol/mg protein, respectively) in clinically significant levels. In particular, BG‐1 has a DNA index of 1.14, a stable karyotype with specific translocations, and produces and secretes CA 125 into the media.