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Androgen and estrogen receptors in hepatocellular carcinoma and the surrounding liver in women
Author(s) -
Nagasue Naofumi,
Kohno Hitoshi,
Chang YuChung,
Hayashi Takafumi,
Utsumi Yasuo,
Nakamura Teruhisa,
Yukaya Hirofumi
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890101)63:1<112::aid-cncr2820630118>3.0.co;2-p
Subject(s) - hepatocellular carcinoma , medicine , cirrhosis , estrogen receptor , androgen receptor , androgen , receptor , liver disease , endocrinology , estrogen , carcinoma , gastroenterology , pathology , hormone , cancer , breast cancer , prostate cancer
Androgen receptors (AR) and estrogen receptors (ER) were consecutively assayed for hepatocellular carcinoma (HCC) and the surrounding liver was removed surgically from 19 female patients. Patient age ranged from 43 to 79 years, with an average of 61 ±9 years. All patients had underlying liver disease (liver cirrhosis in 16, liver fibrosis in two, and chronic hepatitis in one). Seven (37%) of 19 HCC had AR ranging from 2.3 to 82.6 fmol/mg of cytosol protein. The AR titer was higher in the HCC than in the liver in these cases. Three cases also had ER. ER existed in seven (37%) tumors (range, 2.4 to 25.6 fmol/ mg of protein). AR and ER were detected in 11 (65%) and ten (58%) of 17 nonneoplastic liver tissues, respectively. Serum alpha‐fetoprotein (AFP) level, hepatitis B virus markers, or histopathologic types of HCC had no correlation with the presence or absence of AR or ER and their titers. Also, there was no correlation between the AR and ER positivities. Further studies are mandatory to determine the genuine role of sex hormone receptors in the development and growth of HCC in humans.