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Alveolar soft‐part sarcoma. A clinico‐pathologic study of half a century
Author(s) -
Lieberman Philip H.,
Brennan Murray F.,
Kimmel Marek,
Erlandson Robert A.,
GarinChesa Pilar,
Flehinger Betty Y.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890101)63:1<1::aid-cncr2820630102>3.0.co;2-e
Subject(s) - medicine , alveolar soft part sarcoma , soft tissue , radiation therapy , sarcoma , surgery , soft tissue sarcoma , neoplasm , immunohistochemistry , radiology , pathology
In the period from 1923 to 1986 our pathologists examined pathologic material from 102 patients with alveolar soft‐part sarcoma (ASPS). Followup clinical data is available for 91. Median followup is 7 years (range 1 month to 27 years). Local recurrence was only found if residual disease was left at the time of the original excision. Survival in those patients who presented without metastases was 77% at 2 years, 60% at 5 years, 38% at 10 years and 15% at 20 years (median 6 years). No survival advantage could be demonstrated for patients who received chemo and/or radiotherapy, although numbers are small and staging not uniform. An evaluation by electron microscopy and immunohistochemistry cannot confirm recent claims that ASPS is a muscle tumor. ASPS is an unusual neoplasm; the primary therapeutic option is aggressive surgical excision. Survival even with the development of metastases can be long.