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Fragile X syndrome and acute lymphoblastic leukemia
Author(s) -
Cunningham Michael,
Dickerman Joseph D.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881201)62:11<2383::aid-cncr2820621122>3.0.co;2-r
Subject(s) - fragile x syndrome , malignancy , medicine , chromosomal fragile site , lymphoblastic leukemia , x chromosome , leukemia , chronic lymphocytic leukemia , acute lymphocytic leukemia , pathology , chromosome , genetics , biology , psychiatry , gene
Fragile X (Fra(X) syndrome is an example of a heritable fragility syndrome associated with mental retardation. It is characterized by a fragile site on the X chromosome at Xq27–28. There have recently been three reports of malignant solid tumors associated with Fra(X) syndrome. We describe the first case of a hematologic malignancy [T‐cell acute lymphocytic leukemia (ALL)] in a patient with Fra(X) syndrome. The possibility of a predisposition to malignancy in Fra(X) is discussed.