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Meningeal hematopoiesis causing exophthalmus and hemiparesis in myelofibrosis: Effect of radiotherapy: A case report
Author(s) -
Landolfi Raffaele,
Colosimo Cesare,
de Candia Erica,
Castellana Maria Angela,
de Cristofaro Raimondo,
Trodella Lucio,
Leone Giuseppe
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881201)62:11<2346::aid-cncr2820621115>3.0.co;2-e
Subject(s) - medicine , hemiparesis , myelofibrosis , radiation therapy , extramedullary hematopoiesis , radiology , exophthalmus , surgery , bone marrow , pathology , eye disease , haematopoiesis , lesion , genetics , stem cell , biology
Meningeal myeloid metaplasia (MM) is very rarely observed in patients with myeloflbrosis. We report the occurrence of meningeal MM causing exophthalmus and fever in a patient with myelofibrosis secondary to polycythemia vera. A computerized tomography (CT) scan showed multiple intracranial and intraorbital enhancing masses. A needle aspirate of retrobulbar space confirmed the diagnosis of extramedullary hematopoiesis. The patient subsequently developed a rapidly worsening tumor‐like syndrome with hemiparesis, aphasia, and loss of sphinteric control. The administration of radiotherapy caused a complete and stable regression of clinical symptoms and a marked reduction of MM masses.