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Combined floxuridine® and cisplatin in a fourteen day infusion: Phase I study
Author(s) -
Lokich Jacob,
Anderson Norwood,
Bern Murray,
Wallach Sabina,
Moore Cherie,
Williams David,
Umprain Vimonrat
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881201)62:11<2309::aid-cncr2820621109>3.0.co;2-z
Subject(s) - floxuridine , cisplatin , medicine , maximum tolerated dose , dose rate , continuous infusion , toxicity , chemotherapy , pharmacology , gastroenterology , urology , fluorouracil , medical physics
Twenty patients received 28 courses of 5FUDR® (floxuridine) admixed with Cisplatin (CDDP) and administered as a continuous infusion for 24 hours for 14 consecutive days. Pharmaceutical studies of the admixture of 5FU with CDDP and 5FUDR with CDDP demonstrated that only 5FUDR was compatible with CDDP and that the admixture was stable for 7 days. This Phase I study established the optimal dose rate for the individual components of the admixture and demonstrated that CDDP decreases the maximum tolerated dose rate for 5FUDR. The optimal dose rate for 5FUDR is 0.075 mg/Kg/d, and for CDDP the optimal dose rate is 7.5 mg/M 2 /d. Dose rate limiting toxicity is an enteritis which is radiographically similar to regional enteritis and is related to the 5FUDR. An ancillary finding was a significant decrease in serum magnesium levels in 11 of 13 monitored courses presumably related to the platinum.