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Activity of porphobilinogen deaminase in peripheral blood mononuclear cells of patients with metastatic cancer
Author(s) -
Leibovici Leonard,
Schoenfeld Nili,
Yehoshua Henry A.,
Mamet Rivka,
Rakowsky Erica,
Shindel Asher,
Atsmon Abraham
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881201)62:11<2297::aid-cncr2820621106>3.0.co;2-7
Subject(s) - porphobilinogen deaminase , medicine , peripheral blood mononuclear cell , porphobilinogen , cancer , enzyme , peripheral blood , adenosine deaminase , peripheral , heme , pathology , cancer research , lactic dehydrogenase , porphyria , acute intermittent porphyria , biochemistry , biology , in vitro , adenosine
Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.