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Dietary vitamins A and C and lung cancer risk in louisiana
Author(s) -
Fontham Elizabeth T. H.,
Pickle Linda Williams,
Haenszel William,
Correa Pelayo,
Lin Youping,
Falk Roni T.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881115)62:10<2267::aid-cncr2820621033>3.0.co;2-e
Subject(s) - medicine , odds ratio , lung cancer , confidence interval , retinol , adenocarcinoma , vitamin c , cancer , vitamin , gastroenterology , case control study , adenocarcinoma of the lung , physiology
The authors describe the results of a hospital‐based incident case‐control study of lung cancer conducted in a high‐risk region of southern Louisiana from January 1979 through April 1982. Dietary intake of carotene, retinol, and vitamin C was estimated from food frequency questionnaires administered to 1253 cases and 1274 controls. An inverse association was found between level of carotene intake and lung cancer risk, and this protective effect was specific for squamous and small cell carcinoma (odds ratio (OR) = 0.84, 95% confidence interval: 0.64–1.09, high intake). A stronger protective effect for these tumors was associated with dietary vitamin C intake (OR = 0.65, 0.50–0.87, high intake). A significant inverse gradient in risk with retinol intake was limited to adenocarcinoma (OR = 0.64, 0.44–0.94, high intake) and more pronounced among blacks.