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A lethal neurotoxic reaction after intraventricular methotrexate administration
Author(s) -
Hoeve Rita F. A. Ten,
Twijnstra Albert
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881115)62:10<2111::aid-cncr2820621007>3.0.co;2-v
Subject(s) - medicine , methotrexate , neurotoxicity , autopsy , pathophysiology , lung , anesthesia , toxicity , pathology , surgery
A case of a patient with leptomeningeal metastases from an adenocarcinoma of the lung is described. She developed a fatal neurologic reaction during intraventricular administration of methotrexate. No morphologic cause of death was found during autopsy. Similar cases of acute complications are discussed, and an outline of factors that might play a role in the pathophysiology of methotrexate neurotoxicity is given.