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Endodermal sinus tumor and mucinous cystadenofibroma of the ovary: Occurrence in an 82‐year‐old woman
Author(s) -
Mazur Michael T.,
Talbot William H.,
Talerman Aleksander
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881101)62:9<2011::aid-cncr2820620923>3.0.co;2-y
Subject(s) - carcinoembryonic antigen , medicine , endodermal sinus tumor , pathology , ovary , mucin , ovarian tumor , neoplasm , mucinous tumor , germ cell tumors , ovarian cancer , cancer , chemotherapy , pancreas
We encountered an unusual ovarian tumor consisting of a mixture of typical endodermal sinus tumor (EST) and mucinous Cystadenofibroma that occurred in the ovary of an 82‐year‐old female patient. The EST component showed the classic histologic features of this tumor. Serum alpha‐fetoprotein (AFP) level was not determined. Tumor stains were negative for AFP but positive for alpha‐1‐antitrypsin. The malignant germ cell component was intimately associated with the benign mucinous component. Focal production of epithelial mucin and carcinoembryonic antigen (CEA) in the EST component suggested a probable association between the two tumor types. The tumor was confined to one ovary, and the patient is disease‐free 2 years after surgical therapy. This neoplasm is unique not only for the malignant germ cell component occurring in an 82‐year‐old woman, but for the unusual combination of tumor types. The pathogenesis is unknown.