Premium
A unique pattern of proto‐oncogene abnormalities in ovarian adenocarcinomas
Author(s) -
Zhou D. J.,
GonzalezCadavid N.,
Ahuja H.,
Battifora H.,
Moore G. E.,
Cline M. J.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881015)62:8<1573::aid-cncr2820620819>3.0.co;2-m
Subject(s) - oncogene , gene duplication , adenocarcinoma , medicine , ovarian cancer , pathology , cancer research , ovary , cancer , biology , gene , cell cycle , genetics
Twelve cases of ovarian adenocarcinoma were studied for alterations in proto‐oncogenes, and a unique pattern of altered ras proto‐oncogenes was observed. Amplification of ras‐Ki was found in three of seven ovarian tumors and amplification of ras ‐Ha in one of 12. In contrast, ras ‐Ha amplification was not found in any of the 334 other tumors and ras ‐Ki amplification was only seen in breast cancer at a frequency of 3%. Other proto‐oncogenes altered in ovarian adenocarcinomas included c‐myc and c‐erbb ‐2. Proto‐oncogene abnormalities were more frequent in aggressive tumors of high histologic grade.