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The gene responsible for the development of retinoblastoma and osteosarcoma
Author(s) -
Benedict William F.,
Fung Yuenkai T.,
Murphree A. Linn
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881015)62:1+<1691::aid-cncr2820621306>3.0.co;2-5
Subject(s) - retinoblastoma , osteosarcoma , gene , cancer research , medicine , gene expression , allele , cancer , genetics , biology
The gene responsible for the formation of both retinoblastoma and osteosarcoma recently has been isolated. This represents the first human recessive cancer gene ever cloned. Structural deletions within one or both retinoblastoma gene alleles were commonly noted in the retinoblastomas and an osteosarcoma. Whether or not changes were observed at the DNA level there was either no expression or an abnormal expression of the gene in the tumor. The fact that we could detect changes in the fibroblasts of some patients with the hereditary form of retinoblastoma also indicates that the gene can be used for diagnostic purposes.