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Carcinogen testing fact and fallacy
Author(s) -
Moore John A.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881015)62:1+<1688::aid-cncr2820621305>3.0.co;2-p
Subject(s) - medicine , fallacy , animal testing , carcinogen , term (time) , risk analysis (engineering) , toxicology , epistemology , biology , genetics , philosophy , physics , quantum mechanics
In the absence of human information on the carcinogenicity of chemical substances, one must rely primarily on information from long‐term animal testing. Although far from perfect, animal studies seem to be reasonable predictors of the human experience, both qualitatively and quantitatively. Short‐term tests for genotoxicity may be helpful for establishing priorities for chemical testing, but they are not as strong indicators of potential carcinogenicity as had been previously thought. New directions in toxicologic research hold the promise for scientists being able to perform more reasoned assessments of carcinogenic risk.