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Risk of nonocular cancer among retinoblastoma patients and their parents: A population‐based study in Denmark, 1943–1984
Author(s) -
Winther Jens,
Olsen Jørgen H.,
de Nully Brown Peter
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881001)62:7<1458::aid-cncr2820620735>3.0.co;2-2
Subject(s) - medicine , retinoblastoma , confidence interval , relative risk , population , cancer , gynecology , genetics , biology , environmental health , gene
The risk of nonocular cancer among survivors of retinoblastoma has been investigated in a populationbased study in Denmark, 1943 to 1984. None of the survivors had been treated with chemotherapeutic drugs. Forty‐eight patients were treated with x‐rays, and 102 patients were treated primarily with surgical removal of the eye(s). The overall relative risk (RR) for a new primary cancer was 4.2 (95% confidence limits, 1.1–11.5). In the subgroup of genetic retinoblastoma the risk was 15.4 (95% confidence limits, 2.6–50.8) and in the group of nonhereditary cancer the risk was 1.7 (95% confidence limits, 0.1–8.5). For all retinoblastoma patients the RR of bone cancer was 100 (95% confidence limits, 17–330). Parents not having retinoblastoma themselves were not at increased risk for nonocular cancer.