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Carcinoma of the gallbladder: A clinicopathology of 103 patients and a newly proposed staging
Author(s) -
Yamaguchi Koji,
Enjoji Munetomo
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881001)62:7<1425::aid-cncr2820620730>3.0.co;2-t
Subject(s) - gallbladder , carcinoma , medicine , dysplasia , pathology , adenocarcinoma , stage (stratigraphy) , carcinoembryonic antigen , gastroenterology , cancer , biology , paleontology
Tissue samples from 103 patients with gallbladder carcinoma were examined, using 5‐mm stepwise tissue sections. Three pathologic stages were used: Stage I; carcinoma invading not further than the muscle coat of the gallbladder, with or without extension along Rokitansky‐Aschoff sinuses in the subserosa (11 cases); Stage II, carcinoma extending to the subserosal fibroadipose tissue of the gallbladder (73 cases); and Stage III: carcinoma invading the adjacent organs such as the duodenum, liver, and colon (19 cases). In the 11 patients with Stage I carcinoma, there was no apparent lymph node metastasis and all remained well for 3 months to 14 years after the initial operation. The cumulative 3‐year survival rate of Stage I (100%) was significantly higher than of Stage II (40%) and Stage III (10%) ( P < 0.01, P < 0.001). The Stage I tumors, therefore, can be defined as early carcinoma of the gallbladder. Dysplastic epithelium was seen in the mucosa adjacent to the malignant lesion in 57% of those with gallbladder carcinoma: 73% in Stage I, 59% in Stage II, and 42% in Stage III. Nine gallbladders had multiple foci of adenocarcinoma in a background of a diffuse dysplasia. Immunohistochemical study for carcinoembryonic antigen and carbohydrate antigen 19‐9 resulted in positive staining of the dysplastic epithelial element adjacent to the invasive carcinoma and, in a similar fashion, in the carcinoma itself, thereby indicating a close relation between the epithelial dysplasia and adenocarcinoma of the gallbladder.