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An analysis of the DNA ploidy patterns of gastric cancer
Author(s) -
Sowa Michio,
Yoshino Hiroaki,
Kato Yasuyuki,
Nishimura Masanori,
Kamino Kenjin,
Umeyama Kaoru
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19881001)62:7<1325::aid-cncr2820620714>3.0.co;2-m
Subject(s) - nuclear dna , cancer , pathology , dna , medicine , metastasis , stage (stratigraphy) , lymph node , lymph node metastasis , cancer cell , oncology , biology , genetics , gene , mitochondrial dna , paleontology
This article deals with DNA measurements by fluorometry of nuclei in 33 freshly obtained specimens and in 109 fixed specimens of gastric cancer in Japanese patients. Histograms of the DNA measurements can be classified into four types (Ia, Ib, II, III). The nuclear DNA patterns had definite, if not significant, correlations with clinical and histologic parameters. For example, 88.2% of the cases classified as Type III were advanced stage disease, whereas early stage cases were predominant in Type Ia. Type II and III were frequently found in hepatic, peritoneal, and lymph node metastasis. The rate of occurrence of polyploid cells was significantly higher in the group with hepatic or lymph node metastasis than in the other group without metastasis. The results of this study show that fluorometric measurement of nuclear DNA is considered one method of determining the biological activity of gastric cancer cells.