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Immunohistochemical demonstration of steroid C21 hydroxylase in normal and neoplastic human breasts
Author(s) -
Sasano Hironobu,
Sasano Nobuaki
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880915)62:6<1183::aid-cncr2820620623>3.0.co;2-w
Subject(s) - pathology , fibroadenoma , immunohistochemistry , gynecomastia , medicine , neoplastic transformation , carcinoma , medullary carcinoma , breast fibroadenoma , mammary gland , dysplasia , breast cancer , cancer , carcinogenesis , thyroid , thyroid carcinoma
Steroid C21 hydroxylase was investigated immunohistochemically with the use of antibody against cytochrome P‐450 specific for steroid C21 hydroxylation (P‐450 C21 ) in normal and neoplastic human breast tissues. In the histologically normal breast, P‐450 C21 was exclusively present in secretory tubules and ducts. In mammary dysplasia and fibroadenoma, P‐450 C21 was intensively stained in epithelial cells. In gynecomastia, P‐450 C21 was faintly observed in epithelial cells in some cases. In intraductal and invasive ductal carcinoma, P‐450 C21 was observed in the cells with ductal formation. P‐450 C21 was not observed in medullary and mucinous carcinoma. In lobular carcinoma, only two cases were positive for P‐450 C21 of nine cases examined. P‐450 C21 is considered to be closely related to the ductal differentiation in neoplastic transformation of the breast.