Premium
Expression of schwann cell characteristics in pigmented nevus. Immunohistochemical study using monoclonal antibody to schwann cell associated antigen
Author(s) -
Aso M.,
Hashimoto K.,
Eto H.,
Fukaya T.,
Ishihara M.,
Shimao S.,
Shimizu Y.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880901)62:5<938::aid-cncr2820620515>3.0.co;2-2
Subject(s) - schwann cell , monoclonal antibody , antigen , immunohistochemistry , nevus , pathology , neurofilament , antibody , medicine , biology , microbiology and biotechnology , immunology , cancer research , melanoma
A monoclonal antibody to the Schwann cell associated antigen (AHMY1) and a monoclonal antibody to neurofilament proteins (NFP) (AHNF1) each were produced. Using AHMY1, AHMF1, and anti‐S‐100 antibody, 90 pigmented nevi were examined immunohistochemically to clarify the relationship between nevus cells and Schwann cells. All nevus cells had S‐100 protein, but did not have neurofilament proteins. The nevic corpuscle and Type C nevus cell were positively stained with AHMY1 indicating the presence of the Schwann cell associated antigen, while Type A and B nevus cells were entirely negative. This suggests that the nevic corpuscle and Type C nevus cell are closely related to the Schwann cell and differ from Type A and B nevus cells in their development.