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Hepatic tumors with hyperglucagonemia response to treatment with human lymphoblastoid interferon
Author(s) -
SheehanDare Robert A.,
Simmons Adrian V.,
Cotterill John A.,
Janke Phillip G.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880901)62:5<912::aid-cncr2820620510>3.0.co;2-0
Subject(s) - hyperglucagonemia , medicine , glucagonoma , lymphoblast , glucagon , rash , hepatoblastoma , gastroenterology , pathology , endocrinology , insulin , biology , genetics , cell culture
A 62‐year‐old man had necrolytic migratory erythema in association with hyperglucagonemia and multiple hepatic tumors. A diagnosis of metastatic glucagonoma was made. He was treated with human lymphoblastoid interferon given subcutaneously in the dose of 2.8 to 7.1 × 10 6 IU/day. This produced a considerable fall in plasma glucagon and resolution of the associated rash. The treatment was continued for 10 weeks over a 4‐month period. Computed tomography demonstrated a reduction in hepatic tumor mass.