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Removal of methotrexate, leucovorin, and their metabolites by combined hemodialysis and hemoperfusion
Author(s) -
Relling Mary V.,
Stapleton F. Bruder,
Ochs Judith,
Jones Deborah P.,
Meyer William,
Wainer Irving W.,
Crom William R.,
McKay Charles P.,
Evans William E.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880901)62:5<884::aid-cncr2820620506>3.0.co;2-a
Subject(s) - hemoperfusion , hemodialysis , methotrexate , medicine , creatinine , dialysis , gastroenterology , surgery , pharmacology
This article documents the case of a patient with severe renal failure immediately after having been given high‐dose methotrexate; the patient was effectively treated with repeated hemodialysis, charcoal hemoperfusion, leucovorin, and thymidine. The methotrexate plasma concentration was reduced from 390 μmol/L to 7 μmol/L as a result of 24.5 hours of hemodialysis along with 39.5 hours of hemoperfusion. Although a rebound in the plasma methotrexate concentration occurred the first three times that hemodialysis and/or hemoperfusion was stopped, reinstitution of the procedure was always effective in further lowering methotrexate concentrations. The patient was subsequently managed with leucovorin and thymidine rescue. Simultaneous measurements before and after the hemodialysis‐hemoperfusion apparatus and before and after the hemoperfusion device alone revealed a percent decrease in the concentration of d‐leucovorin of 36% and 79%; 1‐leucovorin, 82% and 75%; 5‐methyltetrahydrofolate, 52% and 64%; methotrexate, 73% and 37%; and 7‐hydroxymethotrexate, 21% and 24%, respectively. Gastrointestinal and hematologic toxicities were completely prevented, and serum creatinine normalized within 24 days.