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High‐voltage irradiation and combination chemotherapy for malignant pheochromocytoma
Author(s) -
Siddiqui Mohammed Z.,
Von Eyben Finn E.,
Spanos George
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880815)62:4<686::aid-cncr2820620407>3.0.co;2-7
Subject(s) - medicine , paraplegia , dacarbazine , vincristine , pheochromocytoma , cyclophosphamide , chemotherapy , radiation therapy , irradiation , urology , spinal cord , physics , psychiatry , nuclear physics
A 29‐ year‐old man with metastatic extraadrenal pheochromocytoma developed paraplegia which reversed completely after megavoltage irradiation of the dorsolumbar spine. Later, treated with cyclophosphamide, vincristine, and dacarbazine, he had a temporary decrease in plasma norepinephrine concentration, a partial recalcification of bone lesions, and a decrease in the need for antihypertensive treatment for 12 months. Irradiation and combination chemotherapy should be evaluated further in the management of malignant pheochromocytoma.