Premium
Paget's disease of the male breast
Author(s) -
Serour F.,
Birkenfeld S.,
Amsterdam E.,
Krispin M.,
Treshchan O.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880801)62:3<601::aid-cncr2820620326>3.0.co;2-7
Subject(s) - medicine , modified radical mastectomy , radical mastectomy , adjuvant , axillary lymph nodes , incidence (geometry) , radiation therapy , hormone , disease , mastectomy , surgery , hormone therapy , hormonal therapy , adjuvant therapy , lymph , dermatology , breast cancer , pathology , cancer , chemotherapy , physics , optics
Histologically proved Paget's disease of the breast with negative hormonal receptor assay in a 73‐year‐old man induced a review of the 27 valuable cases of the literature. Our patient is disease‐free, eight years after treatment by modified radical mastectomy and adjuvant irradiation. Peak incidence of the disease is between 50 and 70 years of age. The most frequent presenting signs reported are ulcerations and eczematous lesions of the nipple (71.4%) with discharge and bleeding in 39.3% of the cases. Other findings are a palpable mass (42.8%) and involved axillary lymph nodes (53.5%). The treatment of choice is shown to be radical or modified radical mastectomy with adjuvant radiotherapy. To date, no proof exists of the value of hormone receptors assays and routine adjuvant hormone therapy is not practiced.