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Prognostic factors in gestational trophoblastic tumors. A multivariate analysis
Author(s) -
Azab Mohamed B.,
Theodore Christine,
Droz JeanPierre,
Amiel JeanLouis,
Pejovic MarieHelene,
George Martine,
Bellet Dominique,
Michel Guy
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880801)62:3<585::aid-cncr2820620324>3.0.co;2-x
Subject(s) - medicine , multivariate analysis , trophoblastic tumor , multivariate statistics , obstetrics , gynecology , oncology , gestation , pregnancy , statistics , mathematics , biology , genetics
One hundred sixty‐two gestational trophoblastic tumors (GTT) were treated at the Institute Gustave‐Roussy, Villejuif, France, from 1975 to 1985. Sustained complete remission (CR) was obtained in 146 patients (90%). All 97 patients with no histologic diagnosis of choriocarcinoma were cured, including 19 patients considered at high risk initially. Among 65 histologic chariocarcinoma patients, 16 died (CR, 75.5%) including seven initially nonmetastatic patients. Using a univariate analysis, all factors tested in the whole group of patients were more or less significant except for age and parity. However, when the same variables were tested in patients considered at high risk initially, only three factors were statistically significant. Those three factors were the only ones associated with a statistically significant higher relative death risk (RR) on multivariate analysis and are as follows: an antecedent nonmolar pregnancy (RR = 4.3; P < 0.01); initial presentation with more than one metastatic organ (RR = 7.4; P < 0.01); and primary resistance to single agent (RR = 18.8; P < 0.0001) or multi‐agent chemotherapy (RR = 26.1; P < 0.0001). It seems that those three factors, together with a histologic diagnosis of choriocarcinoma, are the prognostic factors that discriminate patients with unfavorable outcomes among the high‐risk group.