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Prognostic factors in advanced nonseminomatous testicular cancer a multivariate logistic regression analysis
Author(s) -
Droz Jean P.,
Ghosn Marwane,
Piot Gilles,
Theodore Christine,
Pico Jose L.,
Hayat Marcel,
Kramar Andrew,
Rey Annie,
Wibault Pierre,
Court Bernard H.,
Perrin Jean L.,
Travagli Jean P.,
Bellet Dominique,
Caillaud J. M.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880801)62:3<564::aid-cncr2820620321>3.0.co;2-a
Subject(s) - medicine , logistic regression , multivariate analysis , proportional hazards model , human chorionic gonadotropin , oncology , testicular cancer , multivariate statistics , prognostic variable , alpha fetoprotein , cancer , gynecology , hormone , statistics , mathematics , hepatocellular carcinoma
In order to define prognostic factors for advanced stage of nonseminomatous germ cell tumors (NSGCT) of the testis, the authors reviewed 84 patients treated from 1978 through 1985. The survival rate was 51% at 3 years. Patients with elevated seric levels of human chorionic gonadotropin (HCG) and/or alpha‐fetoprotein (AFP), or the presence of an abdominal mass had significantly worse survival. Only HCG and AFP levels retained their significance when multivariate Cox analysis was performed. The probability that a patient achieves a complete remission (CR) was assessed by a function of certain patient characteristics using a multivariate logistic regression analysis. The significant variables were a function of HCG and AFP values. Since both variables are related to the CR rate and survival the authors define the obtention of a CR as a unique outcome of interest. The probability of a CR greater than 70% adequately separates the patients into two prognostic subgroups. This model currently is being used to enrole NSGCT patients in a prospective modulated clinical trial according to these prognostic factors.