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Consistency of chromosomal aberrations in chronic B‐lymphocytic leukemia. A longitudinal cytogenetic study of 41 patients
Author(s) -
Juliusson Gunnar,
Friberg Kristina,
Gahrton Gösta
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880801)62:3<500::aid-cncr2820620310>3.0.co;2-w
Subject(s) - karyotype , chronic lymphocytic leukemia , prolymphocytic leukemia , clone (java method) , somatic evolution in cancer , isochromosome , monosomy , cytogenetics , chromosome , medicine , pathology , chromosome abnormality , leukemia , biology , immunology , oncology , cancer , genetics , dna , gene
Serial chromosome analyses with a mean of 3.7 samplings during a mean interval of 4.2 years (range, 1.5 to 8.6 years) were performed on B‐cell mitogen‐activated chronic B‐lymphocytic leukemia (CLL) cells from 41 patients. Twenty‐four of these patients (59%) had progressive disease. Clonal chromosomal aberrations were found in 28 patients; 12 had an extra chromosome 12. Thirty patients (73%), 17 with and 13 without clonal aberrations, retained their karyotype throughout the study, although six lost minor subclones. In five patients (12%), a clonal aberration was found only once. Six patients (15%) showed changes of the karyotype. One treated patient with multiple aberrations acquired another monosomy. Another patient with multiple aberrations and prolymphocytic transformation gained a marker chromosome. One treated patient with an initially normal karyotype acquired two independent clonal aberrations. Three patients lost one subclone but retained another clone that increased in frequency. In two cases, clonal changes were associated with clinical changes. The chromosomal aberrations are mostly established already at diagnosis and mark the disease of the CLL patient. Cytogenetic analysis at any time is representative and useful in the prognosis prediction.