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Dna ploidy is closely linked to tumor invasion, lymph node metastasis, and prognosis in clinical gastric cancer
Author(s) -
Korenaga Daisuke,
Okamura Takeshi,
Saito Atsushi,
Baba Hideo,
Sugimachi Keizo
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880715)62:2<309::aid-cncr2820620214>3.0.co;2-#
Subject(s) - medicine , cancer , lymph node metastasis , metastasis , lymph node , ploidy , pathology , oncology , biology , gene , genetics
DNA ploidy microspectrophotometrically determined in 254 patients with gastric carcinoma was investigated from the standpoint of tumor invasion, lymph node metastasis, and prognosis. DNA distribution patterns were grouped into low and high ploidies. The 24.0% frequency in the high ploidy group, at the mucosal stage, increased in proportion to invasion into the deeper layers. There was a high incidence of lymph node metastasis in the high ploidy group, compared with the low ploidy group, in case of invasion beyond the mucosa. Widespread nodal involvement was frequent in the high ploidy group. The 5‐year survival rate was 73.7% in patients of high ploidy, with a statistical difference compared to the 90.6% in those of low ploidy (P < 0.01). The difference in the survival rates was statistically significant only in those with a metastasis (P < 0.01). In the multivariate analysis of 226 patients undergoing curative surgery, the DNA ploidy proved to be a major independent prognostic factor. These findings indicate a close correlation among DNA ploidy, tumor invasion and nodal involvement, and the significant clinical value of DNA analysis for predicting the prognosis in patients with gastric carcinoma.