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Human immunodeficiency virus‐related lymphoreticular malignancies and peripheral neurologic disease. A report of four cases
Author(s) -
Gold Jay E.,
Jimenez Elpidio,
Zalusky Ralph
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880601)61:11<2318::aid-cncr2820611129>3.0.co;2-3
Subject(s) - medicine , lymphoma , pathology , sarcoma , autopsy , disease , peripheral , immunodeficiency , human immunodeficiency virus (hiv) , immunology , immune system
The most common human immunodeficiency virus‐related (HIV) malignancies to date include Kaposi's sarcoma and the high‐grade non‐Hodgkin's lymphomas. There also appears to be an association between HIV and an aggressive form of Hodgkin's disease. In addition, there is a spectrum of HIV‐related central and peripheral neurologic syndromes. This article documents four patients with HIV‐associated lymphoma who presented with peripheral neurologic syndromes as part of their neoplastic process. Autopsy results obtained from two of these patients showed direct nerve infiltration by lymphoma. All patients had an elevated serum lactate dehydrogenase (LDH). It is recommended that HIV‐related lymphoma be considered in a high‐risk patient who presents with a peripheral neurologic syndrome especially if there is an elevated serum LDH.