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Malignant mixed germ cell‐sex cord‐stromal tumors of the ovary associated with isosexual precocious puberty
Author(s) -
Lacson Atilano G.,
Gillis D. A.,
Shawwa Allam
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880515)61:10<2122::aid-cncr2820611032>3.0.co;2-7
Subject(s) - medicine , precocious puberty , ovary , presentation (obstetrics) , stromal cell , germ cell tumors , cord , germ cell , physiology , surgery , hormone , chemotherapy , biology , biochemistry , gene
Two cases of hormonally active, metastasizing malignant mixed germ cell‐sex cord‐stromal tumors are described in otherwise normal prepubertal girls. Isosexual precocity was noted 5 months and 1 month before surgery. One child died 1 year after presentation, and the other was alive, with no apparent tumor, 1 year after diagnosis. These two cases represent the first recorded instance of a unique tumor in which metastases of several cell types were encountered.