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Effects of diphosphonate and X‐Rays on bone lesions induced in rats by prostate cancer cells
Author(s) -
Pollard Morris,
Luckert P. H.,
Scheu John
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880515)61:10<2027::aid-cncr2820611017>3.0.co;2-j
Subject(s) - medicine , ionizing radiation , prostate cancer , scapula , adenocarcinoma , prostate , pathology , cancer , cancer research , anatomy , irradiation , physics , nuclear physics
Prostate adenocarcinoma‐III (PA‐III) cells deposited over the scapula of Lobund‐Wistar (L‐W) rats induced osteolytic and osteoplastic changes in that bone. The osteolytic process was prevented and interrupted by administrations of dichloromethylene diphosphonate (Cl 2 MDP); but the osteoplastic process, once initiated, continued. The latter process was interrupted by ionizing radiation. Treatments of PA‐III‐affected bones with Cl 2 MDP and x‐rays immobilized both osteolytic and osteoplastic processes.