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Oligodendroglial tumors. An immunohistochemical and electron microscopic study
Author(s) -
Sarkar Chitra,
Roy Subimal,
Tandon P. N.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880501)61:9<1862::aid-cncr2820610923>3.0.co;2-x
Subject(s) - glial fibrillary acidic protein , immunohistochemistry , oligodendroglial tumor , pathology , oligodendroglioma , cytoplasm , astrocyte , gfap stain , progenitor cell , medicine , biology , astrocytoma , cancer research , stem cell , microbiology and biotechnology , glioma , central nervous system
Fifty‐five cases of oligodendrogliomas and mixed oligoastrocytomas were evaluated using immunohistochemical (IH) study for glial fibrillary acidic protein (GFAP) and electron microscopic (EM) study. Most of the tumors in both of these groups showed many neoplastic oligodendroglial cells with GFAP‐positive staining in their cytoplasm by IH study. By EM study too, many tumor cells showing features of oligodendroglial cells contained intermediate filaments. Our observations suggested the presence of a transitional form of cells in these tumors. The current study supports the contention that both oligodendrogliomas and oligoastrocytomas arise from a common progenitor cell capable of differentiation into both oligodendrocyte and astrocyte. The nature and degree of differentiation depends probably on gene expression and/or some microenvironmental factors.