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Florodeoxyglucose imaging: A method to assess the proliferative activity of human cancer in vivo. Comparison with DNA flow cytometry in head and neck tumors
Author(s) -
Minn Heikki,
Joensuu Heikki,
Ahonen Aapo,
Klemi Pekka
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880501)61:9<1776::aid-cncr2820610909>3.0.co;2-7
Subject(s) - flow cytometry , in vivo , medicine , cell cycle , cancer , pathology , head and neck cancer , fluorodeoxyglucose , metastasis , head and neck , nuclear medicine , cancer cell , positron emission tomography , biology , immunology , microbiology and biotechnology , surgery
Thirteen patients with malignant head and neck tumors were studied before they were treated with ( 18 F) fluorodeoxyglucose (FDG) imaging and DNA flow cytometry (FCM). The nuclear DNA content and the percentage of proliferative cells (S+G2/M) were compared with the FDG uptake; FDG was retained in the primary tumor and/or neck metastasis in all patients. The accumulation of FDG did not correlate with histologic grade of the tumors, but there was a clear correlation (r = 0.86, P > 0.001) between the proportion of the cells in S+G2/M phases of the cell cycle and the intensity of FDG accumulation. The uptake of FDG by the tumor also correlated with the percentage of S‐phase cells (r = 0.82, P > 0.001). The result suggests that enhanced glucose metabolism, measured by FDG uptake, is associated with the proliferative activity of the tumor. Thus, imaging with FDG may offer a new method to assess the aggressiveness of human cancer growth in vivo .