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Melanocytic atypia in dysplastic nevi. Immunohistochemical and cytophotometrical analysis
Author(s) -
Bergman W.,
Ruiter D. J.,
Scheffer E.,
van Vloten W. A.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880415)61:8<1660::aid-cncr2820610825>3.0.co;2-x
Subject(s) - atypia , dysplastic nevus , pathology , medicine , nuclear atypia , immunohistochemistry , malignant transformation , locus (genetics) , melanoma , nevus , dermatology , biology , cancer research , genetics , gene
In a double‐blind study a correlation was found between the histologically assessed degree of nevomelanocytic atypia in 58 dysplastic nevi (DN) and the presence of two markers associated with malignant transformation. The markers included a marked expression of histocompatibility locus Class I antigens on nevomelanocytes ( P < 0.01) and abnormalities in the nuclear DNA content as measured by DNA cytophotometry ( P = 0.01). Both markers were present in most of the markedly atypical DN, in about half of the moderately atypical DN, and in less than 30% of the mildly atypical DN. These findings suggest that a DN with marked or moderate melanocytic atypia indicates a premalignant condition and identifies a patient at risk for melanoma.