Premium
Circulating cerebriform lymphoid cells (sezary‐type cells) in a b‐cell malignant lymphoma
Author(s) -
O'Briain D. Sean,
Lawlor Emer,
Sarsfield Patrick,
Cooney Colm,
Blaney Claire H.,
Sullivan Frank J.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880415)61:8<1587::aid-cncr2820610816>3.0.co;2-b
Subject(s) - pathology , lymphoma , medicine , lymph node , calla , antibody , immunology , monoclonal antibody
Circulating cerebriform lymphoid cells (Sezary cells) are considered to be highly predictive of cutaneous T‐cell Lymphoma (CTCL). A leukemic peripheral blood (leukocyte count 24.5 × 10 9 /l) composed predominantly of cerebriform cells was found in a 75‐year‐old man presenting with weight loss and generalized lymphadenopathy but without skin lesions. Cell suspensions studies and immunohistochemistry of peripheral blood revealed that the cerebriform cells were B‐cells (IgM+ Kappa+, HLA DR+, Leu 1+, CALLA‐, B1+, and OKT 10+). A variety of T‐cell markers (other than Leu1) was negative. Computer‐assisted morphometry confirmed a nuclear profile typical of CTCL (mean nuclear contour index, 7.47). A lymph node that underwent subsequent biopsy revealed a follicular malignant lymphoma of small to intermediate cells with similar morphologic and immunologic characteristics to the circulating cerebriform cells. The findings of a leukemic presentation of a cerebriform B‐cell lymphoma extends the recent observation of nodal B‐cell lymphomas composed of cerebriform cells and indicates that circulating cerebriform cells should not be considered to be exclusively of T‐cell origin.