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Unusual Breast Masses. The sequential development of mammary tuberculosis and Hodgkin's disease in a young woman
Author(s) -
GraemeCook Fiona,
Sean O'Briain D.,
Daly Peter A.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880401)61:7<1457::aid-cncr2820610730>3.0.co;2-d
Subject(s) - medicine , tuberculosis , left breast , disease , breast cancer , immune system , pathology , cancer , immunology
A left breast mass developed in association with pulmonary tuberculosis in a woman 26 years of age. Eight years later, rapidly fatal Hodgkin's Disease with chest wall erosion by involved mediastinal nodes simulating a breast lump developed. Subsequently, a discrete breast mass due to mammary Hodgkin's disease developed. Involvement of the breast by both tuberculosis and Hodgkin's disease, two diseases often associated with immune dysfunction, in a patient with dysmorphic features and a strong family history of tuberculosis, raises the possibility of an underlying genetic defect. This defect probably involves the immune system.