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Cerebral germinomas and klinefelter syndrome. A review
Author(s) -
Arens Raanan,
Marcus Daniel,
Engelberg Santiago,
Findler Gideon,
Goodman Richard M.,
Passwell Justen H.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880315)61:6<1228::aid-cncr2820610628>3.0.co;2-r
Subject(s) - klinefelter syndrome , medicine , germinoma , pediatrics , pathology , radiation therapy
Patients with Klinefelter syndrome appear to be predisposed to the development of extragonadal cerebral germinomas. A case of a pineal region germinoma in a boy 15 years of age with Klinefelter syndrome is documented in this article. In view of three other cases of cerebral germinomas associated with Klinefelter syndrome in the literature, a hypothesis for this predisposition is suggested.