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Prognostic value of the flow cytometric DNA index in human ovarian carcinoma
Author(s) -
Iversen OleErik
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880301)61:5<971::aid-cncr2820610519>3.0.co;2-j
Subject(s) - medicine , aneuploidy , ovarian carcinoma , flow cytometry , oncology , carcinoma , prospective cohort study , ploidy , pathology , disease , gastroenterology , ovarian cancer , cancer , immunology , biology , chromosome , gene , biochemistry
Flow cytometric measurements were done on 51 ovarian carcinoma specimens collected from consecutive patients in a prospective study. The ploidy status was related to the course of the disease. The tumors from 26 (52%) of 50 evaluable patients had DNA aneuploidy. Patients with diploid tumors were more often considered disease‐free after initial operation ( P < 0.01). Patients with aneuploid tumors had a more aggressive course of the disease in all respects of comparison. The median survival of patients with diploid tumors was 18 months as compared to 8 months for those with aneuploid tumors ( P < 0.0005). Flow cytometric DNA measurements give important prognostic information and such analyses should be included in future clinical trials. Through the development of high‐speed instrumentation they also may become feasible in routine clinical work.