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Absence of white matter changes on magnetic resonance imaging in children treated with CNS prophylaxis therapy for leukemia
Author(s) -
Kramer Joel H.,
Norman David,
BrantZawadzki Michael,
Ablin Arthur,
Moore Ida M.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880301)61:5<928::aid-cncr2820610512>3.0.co;2-o
Subject(s) - medicine , white matter , magnetic resonance imaging , lateral ventricles , radiology , childhood leukemia , methotrexate , nuclear medicine , leukemia , pathology , lymphoblastic leukemia , surgery
Previous studies have shown that magnetic resonance imaging (MRI) is sensitive to white matter changes in children receiving cranial radiation of 3000 cGy or greater. The current study used MRI to investigate the integrity of white matter in children receiving 1800 to 2400 cGy of cranial radiation. Ten survivors of acute lymphoblastic leukemia (ALL) who received intrathecal methotrexate (MTX) and either 1800 or 2400 cGy of cranial radiation were studied with MRI and neuropsychologic testing. Magnetic resonance (MR) scans were normal in nine of ten patients. One patient had prominent and asymmetrical lateral ventricles and mildly enlarged cortical sulci. White matter tracts were normal in appearance. However, seven of nine children had below average intellectual functioning. Results indicate that children receiving less than 2500 cGy of cranial radiation fail to show white matter changes on MRI, despite evidence of cognitive impairment.