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Vascular and neural invasion in colorectal carcinoma. Incidence and prognostic significance
Author(s) -
Krasna Mark J.,
Flancbaum Louis,
Cody Ronald P.,
Shneibaum Shlomo,
Ari Gur Ben
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880301)61:5<1018::aid-cncr2820610527>3.0.co;2-h
Subject(s) - medicine , vascular invasion , incidence (geometry) , carcinoma , colorectal cancer , pathology , stage (stratigraphy) , gastroenterology , cancer , biology , paleontology , physics , optics
The incidence and significance of histologic vascular and/or neural invasion in 77 patients with colorectal carcinoma treated over a 6‐year period were analyzed retrospectively. Vascular invasion was found in 37.6% of patients and neural invasion in 14.3%. The following three types of vascular invasion were identified: tumor lining epithelium, tumor thrombi, and destruction of the vessel wall. The incidence of metastases in patients with vascular invasion was 60% as opposed to 17% in those without vascular invasions ( P < 0.0001). Survival in these patients was 29.7% and 62.2%, respectively ( P < 0.003). Metastases were found in 72.7% of patients with neural invasion, as opposed to 27% of those without neural invasion ( P < 0.01). Survival was 29.6% as opposed to 57.7% in those without neural invasion ( P < 0.003). Even among patients in the same Dukes' stage, prognosis, as determined by incidence of recurrence, metastases, and survival, was worse significantly among those patients demonstrating vascular invasion ( P < 0.03). Examination of patients with colorectal carcinoma for the presence of vascular and neural invasion may provide useful information for determining future treatment and prognosis.