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Hypercalcemia in childhood renal tumors
Author(s) -
Jayabose Somasundaram,
Iqbal Khalid,
Newman Leonard,
Filippo Joseph A. San,
Davidian Marianna M.,
Noto Richard,
Sagel Inge
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880215)61:4<788::aid-cncr2820610424>3.0.co;2-h
Subject(s) - medicine , complication , metastasis , kidney , renal tumor , metabolic disorder , pathology , nephrectomy , cancer
Hypercalcemia is an uncommon complication of childhood renal tumors. It is exclusively seen in infants 6 months of age or younger with malignant rhabdoid tumor of the kidney (MRTK) or congenital mesoblastic nephroma (CMN). Secretion of parathormone or prostaglandin E 2 by the tumor cells is responsible for the hypercalcemia in most of these patients. Bone metastasis has been notably absent in these patients, and the hypercalcemia completely resolves with the removal of the tumor. Hypercalcemia in itself probably does not have any prognostic significance; however, it may serve as a tumor marker in some patients. Early recognition and effective management of this complication may prevent the acute life‐threatening as well as the longstanding complications of this serious metabolic disorder.