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Immunohistochemical demonstration of steroid C‐21 hydroxylase in normal and neoplastic salivary glands
Author(s) -
Sasano Hironobu,
Ohkubo Tsutomu,
Sasano Nobuaki
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880215)61:4<750::aid-cncr2820610419>3.0.co;2-u
Subject(s) - excretory system , immunohistochemistry , salivary gland , adenolymphoma , pathology , ductal cells , submandibular gland , myoepithelial cell , endocrinology , medicine , biology
The presence of steroid C‐21 hydroxylase in normal and neoplastic salivary glands was investigated immunohistochemically with the use of antibody against cytochrome P‐450 specific for steroid 21‐hydroxylation (P‐450 21 ). In normal salivary glands, P‐450 21 was exclusively present in the excretory duct system (intercalating, striated and large excretory ducts), and not observed in acini. In salivary gland tumors, P–450 21 was observed in most epithelial cells of duct origin within pleomorphic adenomas including cells of amorphous groups scattered in myxoid areas, and in adenolymphoma. Some mucous cells in mucoepidermoid tumor also were positive for this enzyme. These findings in the normal and neoplastic salivary gland suggest that the expression of P‐450 21 is closely related to ductal differentiation.