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Natural history of gastric adenomas in patients with familial adenomatosis Coli/Gardner's syndrome
Author(s) -
Iida Mitsuo,
Yao Tsuneyoshi,
Itoh Hideaki,
Watanabe Hidenobu,
Matsui Toshiyuki,
Iwashita Akinori,
Fujishima Masatoshi
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880201)61:3<605::aid-cncr2820610331>3.0.co;2-l
Subject(s) - medicine , biopsy , natural history , adenoma , endoscopy , antrum , gastroenterology , stomach , surgery , radiology
The natural history of gastric adenomas was studied in 26 patients with familial adenomatosis coli (FAC)/Gardner's syndrome. The patients were followed for an average of 6.8 years (1 year, 5 months to 15 years 4 months) and examined repeatedly using gastric radiography, endoscopy, and biopsy. Gastric adenomas were present in 13 (50%). During the follow‐up period, there was a new appearance of gastric adenomas in six patients but no distinct change in number, size, and histologic features in the remaining seven patients. In a 51‐year‐old man, an antral adenoma that measured 13 mm in diameter and had an irregular central depression did not change in size or morphology during 4 years and 1 month, but malignant change was evident at the time of endoscopic biopsy. The findings indicate that in patients with this disease, gastric adenomas require careful repeated follow‐up examinations using endoscopic biopsy and, if feasible, endoscopic removal is recommended.