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Anthracyclines in the treatment of malignancy in pregnancy
Author(s) -
Turchi Joseph J.,
Villasis Cynthia
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880201)61:3<435::aid-cncr2820610305>3.0.co;2-f
Subject(s) - medicine , pregnancy , malignancy , anthracycline , obstetrics , chemotherapy , gestation , gestational age , fetus , gynecology , surgery , cancer , breast cancer , genetics , biology
This article reports two cases and reviews the literature regarding chemotherapy using anthracyclines during pregnancy. Twenty‐six additional cases using this class of agents to treat malignancy during pregnancy are summarized from 18 reports for a total of 28 pregnancies. Final outcome of pregnancy is analyzed with regard to the following factors: diagnosis, gestational age at start of therapy, total dose of anthracycline, number and type of agents used, neonatal pathologic findings and months of follow‐up of infants. Final outcome of 28 pregnancies resulted in 24 normal infants including a set of twins in the current report. Limited pharmacokinetic information is inconclusive with regard to the appearance of anthracyclines and their known metabolites in placental or fetal tissue.