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A multivariate analysis of pathologic prognostic indicators in large bowel cancer
Author(s) -
Wiggers Theo,
Arends Jan Willem,
Bosman Fred T.,
Schutte Bert,
Volovics Lex
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880115)61:2<386::aid-cncr2820610231>3.0.co;2-j
Subject(s) - carcinoembryonic antigen , medicine , multivariate analysis , proportional hazards model , multivariate statistics , pathology , colorectal cancer , oncology , univariate analysis , stage (stratigraphy) , cancer , univariate , biology , statistics , paleontology , mathematics
A multivariate analysis of the pathologic data of 350 patients with primary colorectal cancer was performed. In addition to conventional parameters such as shape and size of the primary tumor, central node involvement, angioinvasive growth, grade, and stage, new variables such as the immunoreactivity patterns of carcinoembryonic antigen (CEA), CA 19‐9, mucin, serotonin, secretory component (SC), and the DNA index were tested for their potential prognostic value. Every variable except CA 19‐9, serotonin, and DNA showed significant prognostic information in univariate analysis. However, in the multivariate analysis stage was the predictive factor with the highest hazard ratio, but absence of central node involvement, tumors with diameters between 3.5 cm and 6 cm, exophytic tumor growth, well‐differentiated tumors, tumors with CEA immunoreactivity, absence for staining with serotonin, and diploid tumors also were included in the relative risk model. Thus, the afore mentioned variables appear to play a role in the establishment of a prognostic index.