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Alpha‐fetoprotein‐producing renal cell carcinoma
Author(s) -
Morimoto H.,
Tanigawa N.,
Inoue H.,
Muraoka R.,
Hosokawa Y.,
Hattori T.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880101)61:1<84::aid-cncr2820610114>3.0.co;2-i
Subject(s) - medicine , pathology , renal cell carcinoma , alpha fetoprotein , carcinoma , kidney , stain , yolk sac , lung , hepatocellular carcinoma , cancer research , staining , biology , embryo , microbiology and biotechnology
A case of alpha‐fetoprotein (AFP)‐producing renal cell carcinoma with multiple bone and lung metastases, but without liver involvement is reported. The stain specific to AFP (avidin‐biotin complex) proved the presence of the AFP in the cytoplasms of some cells of the renal tumors. In addition, three other cases of AFF‐producing renal cancer recently published in the literature in Japan are reviewed. These four cases indicate that mesoderm‐originating malignant tumors such as renal cell carcinomas can produce AFP in some situations. So, AFP is probably more universal than believed, although it is generally a popular and useful tumor marker for hepatocellular carcinomas and yolk sac tumors. The knowledge of the presence of AFP‐producing renal cell carcinomas will make a new contribution to the study of the oncogenesis of AFP‐producing tumors.