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5‐Fluorouracil‐associated cardiotoxicity
Author(s) -
Freeman Nancy J.,
Costanza Mary E.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880101)61:1<36::aid-cncr2820610108>3.0.co;2-6
Subject(s) - cardiotoxicity , medicine , fluorouracil , myocardial ischemia , cardiology , coronary disease , disease , coronary heart disease , ischemia , chemotherapy
Cardiotoxicity manifested as myocardial ischemia is not generally recognized as a side effect of 5‐fluorouracil. However, there have been at least 35 cases reported since 1975. In only one of these cases was a somewhat detailed evaluation done to rule out underlying coronary disease. The case reported here of 5‐FU cardiotoxicity included an extensive cardiac evaluation to rule out underlying coronary disease and to assess spasm. The literature on 5‐FU cardiotoxicity is also reviewed, and its possible mechanisms are analyzed.