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Reversible ocular toxicity related to tamoxifen therapy
Author(s) -
Ashford Alfred R.,
Donev Irina,
Tiwari Ram P.,
Garrett T. J.
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880101)61:1<33::aid-cncr2820610107>3.0.co;2-i
Subject(s) - medicine , tamoxifen , toxicity , breast cancer , oncology , surgery , cancer
A 42‐year‐old woman with metastatic breast cancer developed bilateral optic disc swelling, retinal hemorrhages, and visual impairment three weeks after starting treatment with low doses of tamoxifen. Neurologic evaluation failed to provide an explanation for the ocular findings which resolved completely after cessation of tamoxifen therapy. This case suggests that tamoxifen has the potential for causing serious ophthalmologic toxicity which may be reversible if recognized early.