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Treatment of retinoblastoma. Results obtained from a prospective study of 51 patients
Author(s) -
Zelter Marta,
Damel Angelica,
Gonzalez Guillermo,
Schwartz Laura,
Gallo Guillermo,
Schvartzman Enrique,
Muriel Federico Sackmann
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880101)61:1<153::aid-cncr2820610126>3.0.co;2-#
Subject(s) - medicine , enucleation , retinoblastoma , optic nerve , radiation therapy , surgery , chemotherapy , orbit (dynamics) , prospective cohort study , ophthalmology , biochemistry , chemistry , engineering , gene , aerospace engineering
During 4 years, 51 patients with retinoblastoma were studied (unilateral 32, and bilateral 19). Treatment consisted of enucleation of those eyes which showed massive involvement followed by radiotherapy when there was optic nerve and/or orbit involvement. Systemic chemotherapy was administered to all patients who underwent nonsurgical treatment and when the histologic examination showed choroidal optic nerve head and/or optic nerve involvement or residual tumor after enucleation. When there was compromise of the central nervous system intrathecal chemotherapy was administered. Nonsurgical treatment consisted of radiotherapy and/or light coagulation. Survival was 90.6% for unilateral cases and 84.2% for the bilateral. The median follow‐up was 31 months and 29 months, respectively. Of 19 conservated eyeballs, 16 preserve useful vision (63%).